Method for the treatment of severe chronic bronchitis (bronchietasis) with an aerosolized antibiotic
AssigneeChiron Corporation
InventorsAlan B. Montgomery, William R. Baker
Life of this patent
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Abstract
The present invention is directed to a method for the treatment of severe chronic bronchitis, i.e., bronchiectasis, using a concentrated aminoglycoside antibiotic formulation delivering the antibiotic to the lung endobronchial space, including alveoli, in an aerosol or dry powder having a mass medium diameter predominately between 1 to 5 microns.
Claims22
A method for the treatment of patients with chronic bronchitis comprising administering to the patient a dry powder or nebulized aerosol formulation comprising from about 1 to about 500 mg of an aminoglycoside antibiotic once or twice daily for at least five days.
A method for the treatment of bronchitis comprising administering to patient in need of such treatment an endobronchial formulation comprising about 250 to about 350 mg of tobramycin dissolved in about 5 ml of solution containing a quarter normal saline adjusted to pH between about 5.5 and 6.5 and administered by nebulization using an ultrasonic nebulizer able to produce predominantly aerosol particle sizes between 1 and 5 microns.
Dependencies are inferred from the claim text.