Compounds that bind growth to hormone receptor
AssigneeDGI BioTechnologies, LLC
InventorsArthur J. Blume, Renee Brissette, Juan Carcamo, Wlodek S. Mandecki, Pauline M. Tang
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Abstract
The present invention provides peptides that bind to the active site of the growth hormone receptor. The present invention also provides methods of using these peptides to identify small organic molecules, which are novel agonists or antagonists of the growth hormone receptor. In addition, the present invention provides kits and therapeutic compositions comprising the peptides that bind to growth hormone receptor.
Claims33
An amino acid sequence which binds specifically to growth hormone receptor and comprises an amino acid sequence selected from the group consisting of SEQ ID NOS:2, 3, 5-8, 11-14, 16-78.
A therapeutic composition comprising an amino acid sequence which binds specifically to growth hormone receptor and comprises an amino acid sequence selected from the group consisting of SEQ ID NOS:2, 3, 5-8, 11-14, 16-78.
An amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence LCQRLGVGWPGWLSGWCAKK (SEQ ID NO:5).
A therapeutic composition comprising an amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence LCQRLGVGWPGWLSGWCAKK (SEQ ID NO:5).
An amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence LCQSWQVTWPGWLAGWCAKK (SEQ ID NO:6).
A therapeutic composition comprising an amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence LCQSWQVTWPGWLAGWCAKK (SEQ ID NO:6).
An amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence DYKDLCQRLGVGWPGWLSGWCA (SEQ ID NO:11).
A kit for identifying a compound which binds growth hormone receptor, comprising:
- a growth hormone receptor and amino acid sequence DYKDLCQRLGVGWPGWLSGWCA (SEQ ID NO:11).
A therapeutic composition comprising an amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence DYKDLCQRLGVGWPGWLSGWCA (SEQ ID NO:11).
An amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence LCQRLGVGWPGWLSGWCA (SEQ ID NO:76).
A kit for identifying a compound which binds growth hormnone receptor, comprising:
- a growth hormone receptor and amino acid sequence LCQRLGVGWPGWLSGWCA (SEQ ID NO:76).
A therapeutic composition comprising an amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence LCQRLGVGWPGWLSGWCA (SEQ ID NO:76).
An amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence DYKDLCQSWQVTWPGWLAGWCA (SEQ ID NO:12).
A kit for identifying a compound which binds growth hormone receptor, comprising:
- a growth hormone receptor and amino acid sequence DYKDLCQSWQVTWPGWLAGWCA (SEQ ID NO:12).
A therapeutic composition comprising an amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence DYKDLCQSWQVTWPGWLAGWCA (SEQ ID NO:12).
An amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence LCQSWQVTWPGWLAGWCA (SEQ ID NO:70).
A kit for identifying a compound which binds growth hormone receptor, comprising:
- a growth hormone receptor and amino acid sequence LCQSWQVTWPGWLAGWCA (SEQ ID NO:70).
A therapeutic composition comprising an amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence LCQSWQVTWPGWLAGWCA (SEQ ID NO:70).
An amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence DYKDLCQSLGVTYPGWLAGWCA (SEQ ID NO:8).
A kit for identifying a compound which binds growth hormone receptor, comprising:
- a growth hormone receptor and amino acid sequence DYKDLCQSLGVTYPGWLAGWCA (SEQ ID NO:
- 8).
A therapeutic composition comprising an amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence DYKDLCQSLGVTYPGWLAGWCA (SEQ ID NO:8).
An amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence LCQSLGVTYPGWLAGWCA (SEQ ID NO:16).
A kit for identifying a compound which binds growth hormone receptor, comprising:
- a growth hormone receptor and amino acid sequence LCQSLGVTYPGWLAGWCA (SEQ ID NO:16).
A therapeutic composition comprising an amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence LCQSLGVTYPGWLAGWCA (SEQ ID NO:16).
An amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence DYKDLCQRLGVTWPGWLAGWCA (SEQ ID NO:14).
A kit for identifying a compound which binds growth hormone receptor, comprising:
- a growth hormone receptor and amino acid sequence DYKDLCQRLGVTWPGWLAGWCA (SEQ ID NO:
- 14).
A therapeutic composition comprising an amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence DYKDLCQRLGVTWPGWLAGWCA (SEQ ID NO:14).
An amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence LCQRLGVTWPGWLAGWCA (SEQ ID NO:44).
A kit for identifying a compound which binds growth hormone receptor, comprising:
- a growth hormone receptor and amino acid sequence LCQRLGVTWPGWLAGWCA (SEQ ID NO:44).
A therapeutic composition comprising an amino acid sequence which binds specifically to growth hormone receptor and comprises amino acid sequence LCQRLGVTWPGWLAGWCA (SEQ ID NO:44).
Dependencies are inferred from the claim text.