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US 6,387,684 B1Granted
Topoisomerase 1-mediated DNA delivery
AssigneeAcademia Sinica
InventorsJaulang Hwang, Cho-Fat Hui, Tzong-Yueh Chen
Life of this patent
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Abstract
The invention relates to a polypeptide having (1) a ligand domain that specifically binds to a molecule on an external surface of a cell, and (2) a DNA binding domain of a Topoisomerase I. The polypeptide optionally contains a translocation domain to facilitate DNA delivery into a cell.
Claims19
A polypeptide consisting of, in any order, one or more ligand domains that specifically bind to a molecule on an external surface of a cell;
- one or more fragments of a Topoisomerase I, each fragment being less than 400 amino acids in length and consisting of an amino acid sequence corresponding to positions selected from the group consisting of 1-300, 51-200, 271-375, 422-596, and 651-696 of a Topoisomerase I;
- and one or more non-Topoisomerase I amino acid sequences.
Dependencies are inferred from the claim text.