Human cDNAs encoding polypeptides having kinase functions
AssigneeImmunex Corporation
InventorsG. Duke Virca, Timothy A. Bird, Dirk M. Anderson, John S. Marken
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Abstract
The invention is directed to purified and isolated human polypeptides having kinase function, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, the use of such polypeptides and fragmented peptides in phosphorylation reactions and as molecular weight markers, the use of such polypeptides and fragmented peptides as controls for peptide fragmentation, the use of such polypeptides in screening assays, and kits comprising these reagents.
Claims24
An isolated polynucleotide molecule comprising the sequence of SEQ ID NO:5 or of SEQ ID NO:13.
An isolated polynucleotide molecule encoding an amino acid sequence comprising the sequence of SEQ ID NO:11, or of SEQ ID NO:14, or of Leu-2 through Val-505 of SEQ ID NO:11.
An isolated polypeptide having kinase activity comprising an amino acid sequence selected from the group consisting of SEQ ID NO:11, SEQ ID NO:14, and the amino acid sequence of Leu-2 through Val-505 of SEQ ID NO:11.
An isolated polynucleotide molecule comprising the sequence of SEQ ID NO:6 or of SEQ ID NO:15.
An isolated polynucleotide molecule encoding an amino acid sequence comprising the sequence of SEQ ID NO:12 or of Pro-2 through Glu-499 of SEQ ID NO:12.
An isolated polypeptide having kinase activity comprising the amino acid sequence of Pro-2 through Glu-499 of SEQ ID NO:12.
Dependencies are inferred from the claim text.