Catalytic monoclonal antibodies with protease activity for selective lysis of protein component of plaques aggregates pathological conditions
AssigneeAbiogen Pharma S.P.A.
InventorsSilvia Trasciatti, Sergio Rosini
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Abstract
Catalytic monoclonal antibodies (abzymes) with selective protease activity in the pathologies characterized by the presence of plaques and fibrillar aggregates with protein component; methods for the preparation thereof and the use thereof as medicaments in the treatment of pathologies such as Alzheimer's disease, amyloidosis, atherosclerosis, prions diseases.
Claims11
An abzyme having protease activity toward aggregate beta amyloid 1-42 protein (Aβ1-42) in a β sheet conformation obtained by immunization with beta amyloid 1-42 protein aggregated in a beta-sheet conformation.
An immunogenic composition comprising Aβ1-42 in a beta-sheet confirmation and a carrier.
Dependencies are inferred from the claim text.