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US 6,387,665 B1Granted
Method of making a vaccine for anthrax
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsBruce Ivins, Patricia Worsham, Arthur M. Friedlander, Joseph W. Farchaus, Susan L. Welkos
Life of this patent
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Abstract
A method of making a vaccine for anthracis that inolves a bacterial expression system and production and use of protective antigen (PA) against Bacillus anthracis. The PA immunogen is useful in a vaccine against human anthrax. The PA can be produced by an asporogenic organism which produces the desired antigen, which is then harvested from the supernatant.
Claims5
A method of making a vaccine comprising:
- incorporating a protective antigen produced by recombinant asporogenic B. anthracis with a pharmaceutically acceptable carrier, wherein said recombinant asporogenic B. anthracis was isolated from a ΔSterne-1(pPA102) strain of bacteria and said recombinant asporogenic B. anthracis does not have the ability to bind a dye when grown on Congo Red Agar.
Dependencies are inferred from the claim text.