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AssigneeGenentech, Inc.
InventorsDavid A. Botstein, Robert L. Cohen, Audrey D. Goddard, Austin L. Gurney, Kenneth J. Hillan, David A. Lawrence, Arnold J. Levine, Diane Pennica, Margaret Ann Roy, William I. Wood
Estimating the term…
Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.
Isolated nucleic acid comprising DNA encoding a human WISP-1 polypeptide having amino acid residues 23 to 367 of FIGS. 3A and 3B (SEQ ID NO:3), or DNA encoding a human WISP-1 polypeptide having amino acid residues 1 to 367 of FIGS. 3A and 3B (SEQ ID NO:4), or a complement of either of the encoding DNAs.
Isolated nucleic acid comprising DNA encoding a human WISP-1 polypeptide having amino acid residues 23 to 367 or 1 to 367 of FIGS. 3A and 3B except for an isoleucine residue at position 184 rather than a valine residue (SEQ ID NOS:
Isolated nucleic acid comprising DNA encoding a human WISP-1 polypeptide having amino acid residues 23 to 367 or 1 to 367 of FIGS. 3A and 3B exccpt for a serine residue at position 202 rather than an alanine residue (SEQ ID NOS:
Isolated nucleic acid comprising DNA encoding a human WISP-1 polypeptide having amino acid residues 23 to 367 or 1 to 367 of FIGS. 3A and 3B except for an isoleucine residue at position 184 rather than a valine residue and except for a serine residue at position 202 rather than an alanine residue (SEQ ID NOS:
Isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO:
Isolated nucleic acid comprising DNA encoding a mouse WISP-1 polypeptide having amino acid residues 23 to 367 of FIG. 1 (SEQ ID NO:11), or DNA oncoding a mouse WISP-1 polypeptide having amino acid residues 1 to 367 of FIG. 1 (SEQ ID NO:12), or a complement of either of the encoding DNAs.
Dependencies are inferred from the claim text.