Pomegranate extracts and methods of using thereof
AssigneeStewart and Lynda Resnick Revocable Trust
InventorsMichael Aviram, Leslie Dornfeld
Life of this patent
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Abstract
Pomegranate extracts and methods of use thereof are provided. Particularly, an antioxidative composition comprising an extract from pomegranate is provided. A method of reducing lipid peroxidation, aggregation or retention, HDL oxidation in a sample and a method of alleviating atherosclerosis in a patient are also provided.
Claims14
A method of ameliorating disorders in a subject associated with a condition selected from the group consisting of low-density lipoprotein oxidation, low-density lipoprotein aggregation, low-density lipoprotein retention, and macrophage oxidation of low-density lipoprotein, the method comprising administering to a subject in need thereof a composition comprising a therapeutically effective amount of an extract from pomegranate, wherein the extract is prepared by a process comprising the steps of:
- (a) crushing, squeezing, and enzymatically treating the whole fruits of pomegranate including inner and outer peels and the seeds to yield a juice component and an insoluble by-product component;
- (b) separating the juice component from the insoluble by-product component;
- (c) resuspending the insoluble by-product component in an aqueous medium;
- (d) crushing, squeezing, and mixing the resuspended by-product component to yield a soluble portion and an insoluble portion;
- (e) separating the soluble portion from the insoluble portion;
- and
- (f) combining the soluble portion with the juice component to produce the extract.
A method of ameliorating disorders selected from the group consisting of arteriosclerotic heart disease and its associated complications, cerebral vascular disease, peripheral vascular disease, abdominal aortic aneurysms, renal artery stenosis, arteriosclerotic disease, disorders associated with transplant complications;
- disorders associated with post-operative heart valve replacement, disorders associated with the arteriosclerotic complications of diabetes mellitus, thrombophlebitis, and other disorders associated with increased numbers of platelets and increased activation of platelets, the method comprising administering to a subject in need thereof a composition comprising a therapeutically effective amount of an extract from pomegranate, wherein the extract is prepared by a process comprising the steps of:
- (a) crushing, squeezing, and enzymatically treating the whole fruits of pomegranate including inner and outer peels and the seeds to yield a juice component and an insoluble by-product component;
- (b) separating the juice component from the insoluble by-product component;
- (c) resuspending the insoluble by-product component in an aqueous medium;
- (d) crushing, squeezing, and mixing the resuspended by-product component to yield a soluble portion and an insoluble portion;
- (e) separating the soluble portion from the insoluble portion;
- and
- (f) combining the soluble portion with the juice component to produce the extract.
A method of ameliorating disorders in a subject associated with a condition selected from the group consisting of low-density lipoprotein oxidation, low-density lipoprotein aggregation, low-density lipoprotein retention, and macrophage oxidation of low-density lipoprotein, the method comprising administering to a subject in need thereof a composition comprising a therapeutically effective amount of an extract from pomegranate, wherein the extract is prepared by a process comprising the steps of:
- (a) crushing, squeezing, and enzymatically treating the whole fruits of pomegranate including inner and outer peels and the seeds to yield a juice component and an insoluble by-product component;
- (b) separating the juice component from the insoluble by-product component;
- (c) resuspending the insoluble by-product component in an aqueous medium;
- (d) crushing, squeezing, and mixing the resuspended by-product component to yield a soluble portion and an insoluble portion;
- and
- (e) separating the soluble portion from the insoluble portion to produce the extract containing the soluble portion.
A method of ameliorating disorders selected from the group consisting of arteriosclerotic heart disease and its associated complications, cerebral vascular disease, peripheral vascular disease, abdominal aortic aneurysms, renal artery stenosis, arteriosclerotic disease, disorders associated with transplant complications;
- disorders associated with post-operative heart valve replacement, disorders associated with the arteriosclerotic complications of diabetes mellitus, thrombophlebitis, and other disorders associated with increased numbers of platelets and increased activation of platelets, the method comprising administering to a subject in need thereof a composition comprising a therapeutically effective amount of an extract from pomegranate, wherein the extract is prepared by a process comprising the steps of:
- (a) crushing, squeezing, and enzymatically treating the whole fruits of pomegranate including inner and outer peels and the seeds to yield a juice component and an insoluble by-product component;
- (b) separating the juice component from the insoluble by-product component;
- (c) resuspending the insoluble by-product component in an aqueous medium;
- (d) crushing, squeezing, and mixing the resuspended by-product component to yield a soluble portion and an insoluble portion;
- and
- (e) separating the soluble portion from the insoluble portion to produce the extract containing the soluble portion.
Dependencies are inferred from the claim text.