Method for producing dispersible sterol and stanol compounds
AssigneeMcNeil-PPC, Inc.
InventorsRichard D. Bruce, Brid Burruano, Michael R. Hoy, Nicholas R. Paquette
Life of this patent
Estimating the term…
Abstract
A method for preparing sterol/stanol and sterol/stanol ester compositions with improved dispersibility is provided by co-melting the sterol/stanol and/or sterol/stanol ester with highly branched hydrocarbons and then grinding the resulting product. A method for preparing the compounds is also disclosed. The ground compound is suitable for formulating into orally administered products suitable for control of blood serum cholesterol.
Claims10
A solid composition suitable to be orally administered comprising a sterol/stanol or sterol/stanol ester composition in an amount sufficient to lower serum cholesterol and an effective amount of a hydrocarbon selected from the group consisting of docusate sodium;
- mono, di and tri glycerides, polyglycolized glycerides, mono-, and di-fatty esters of polyethylene;
- acetylated monoglycerides;
- polyoxyl 40 hydrogenated castor oil;
- and polyoxyethylene 20 sorbitan monopalmitate to provide a water dispersible mixture, wherein the composition is prepared without the intentional addition of water.
A method of producing a water-dispersible dosage form to be orally administered containing a sterol/stanol or sterol/stanol ester comprising:
- a) providing a sterol/stanol or sterol/stanol ester in an amount sufficient to reduce serum cholesterol;
- b) providing a hydrocarbon selected from the group consisting of docusate sodium;
- mono, di and tri glycerides, polyglycolized glycerides, mono-, and di-fatty esters of polyethylene;
- acetylated monoglycerides;
- polyoxyl 40 hydrogenated castor oil;
- and polyoxyethylene 20 sorbitan monopalmitate, polyethylene glycol, polyoxyethylene, polyoxypropylene, and polyoxyethylene/polyoxypropylene co-polymers in an amount sufficient to provide a water dispersible form;
- c) admixing the sterol/stanol or sterol/stanol ester and the hydrocarbon in the absence of water;
- and
- d) grinding the mixture to a particle size of from about 25 to about 75 microns.
A solid composition suitable to be orally administered comprising:
- a sterol/stanol or sterol/stanol ester composition in an amount sufficient to lower serum cholesterol and from about 0.4 to about 10 weight percent polyoxyethylene 20 sorbitan monopalmitate;
- thereby providing a water dispersible mixture, the solid composition free of water.
A method for producing a water-dispersible dosage form to be orally administered containing a sterol/stanol or sterol/stanol ester comprising:
- a) providing a sterol/stanol or sterol/stanol ester in an amount sufficient to reduce serum cholesterol;
- b) providing from about 0.4 to about 10 weight percent polyoxyethylene 20 sorbitan monopalmitate
- c) admixing the sterol/stanol or sterol/stanol ester and the hydrocarbon in the absence of water to provide a water dispersible form.
Dependencies are inferred from the claim text.