Process for preparing pharmaceutical compositions for use with soft gelatin formulations

A process for increasing the concentration of a pharmaceutically active ingredient relative to fill composition viscosity for dosage units comprising the steps of:

• a) combining a first portion of a pharmaceutically active ingredient with substantially the total amount of polyethylene glycol to be used in the fill composition to form an initial suspension, said polyethylene glycol having a molecular weight ranging from about 200 Daltons to about 100,000 Daltons;
• b) mixing said suspension;
• c) adding a first portion of hydroxide ion source to the suspension;
• d) mixing the ingredients until dissolved in solution;
• e) adding a second portion of pharmaceutically active ingredient to the solution to form another suspension;
• f) mixing the suspension;
• g) adding a second portion of hydroxide ion source to the suspension;
• and
• h) mixing the ingredients until dissolved in solution;
• wherein said first and second portions of the pharmaceutically active ingredient and first and second portions of the hydroxide ion source are each less than the total amount of the respective ingredient used in the resulting fill composition.