Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
AssigneeMassachusetts Institute of Technology
InventorsHongming Chen, Robert S. Langer
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Abstract
The present invention relates to targeted polymerized liposomes for oral and/or mucosal delivery of vaccines, allergens and therapeutics. In particular, the present invention relates to polymerized liposomes which have been modified on their surface to contain a molecule or ligand which targets the polymerized liposome to a specific site or cell type. More particularly, the invention relates to the use of polymerized liposomes modified to contain a carbohydrate or lectin on their surface.
Claims37
A polymerized liposome comprising a phospholipid bilayer having phospholipids covalently bonded to each other, an antigen, an adjuvant, and a targeting molecule, wherein the targeting molecule is Ulex Europeans Agglutinin I.
A polymerized liposome suitable for oral delivery of an antigen to a mammal, said polymerized liposome comprising a phospholipid bilayer having phospholipids that are covalently bonded to each other, an antigen, and a targeting molecule, wherein the targeting molecule is a lectin which specifically binds to fucosyl sugars.
A method of delivering an antigen to a mammal, said method comprising administering to said mammal a polymerized liposome comprising a phospholipid bilayer having phospholipids that are covalently bonded to each other, an antigen, an adjuvant, and a targeting molecule, wherein the targeting molecule is Ulex Europeans Agglutinin I.
A method of delivering an antigen to a mammal, said method comprising orally administering to said mammal a polymerized liposome comprising a phospholipid bilayer having phospholipids that are covalently bonded to each other, an antigen, and a targeting molecule, wherein the targeting molecule is a lectin which specifically binds to fucosyl sugars.
A polymerized liposome suitable for oral delivery of an antigen to a mammal, said polymerized liposome comprising a phospholipid bilayer having phospholipids that are covalently bonded to each other, an antigen, and a targeting molecule, wherein the targeting molecule is a lectin which specifically binds to 2′-fucosyllactosamine residues.
A polymerized liposome suitable for oral delivery of an antigen to a mammal, said polymerized liposome comprising a phospholipid bilayer having phospholipids that are covalently bonded to each other, an antigen, and a targeting molecule, wherein the targeting molecule is a lectin which specifically binds to M cells with the proviso that the lectin is not WGA.
A method of delivering an antigen to a mammal, said method comprising orally administering to said mammal a polymerized liposome comprising a polymerized liposome suitable for oral delivery of an antigen to a mammal, said polymerized liposome comprising a phospholipid bilayer having phospholipids that are covalently bonded to each other, an antigen, and a targeting molecule, wherein the targeting molecule is a lectin which specifically binds to 2′-fucosyllactosamine residues.
A method of delivering an antigen to a mammal, said method comprising orally administering to said mammal a polymerized liposome comprising a polymerized liposome suitable for oral delivery of an antigen to a mammal, said polymerized liposome comprising a phospholipid bilayer having phospholipids that are covalently bonded to each other, an antigen and a targeting molecule, wherein the targeting molecule is a lectin which specifically binds to M cells with the proviso that the lectin is not WGA.
Dependencies are inferred from the claim text.