Controlled release insufflation carrier for medicaments

A respirable particle-based pharmaceutical formulation for delivering a medicament via insufflation, comprising controlled release particles of a cohesive composite of a medicament and a pharmaceutically-acceptable carrier comprising locust bean gum wherein the average particle size of the said cohesive composite particles is from about 0.1 to about 125 microns in diameter.

A method of preparing a controlled release pharmaceutical formulation for insufflation therapy, comprising:

• mixing a medicament together with locust bean gum xanthan gum to form a cohesive composite of said medicament and gum and thereafter milling said cohesive composite of said medicament and gum to obtain particles having a diameter from about 0.1 to about 355 microns.

A respirable particle-based pharmaceutical formulation for delivering a medicament, except for G-CSF, via insufflation, comprising controlled release particles of a cohesive composite of a medicament, a pharmaceutically-acceptable carrier comprising a polysaccharide gum and from about 0.1 to about 50% by weight of a cationic cross-linking agent comprising an alkaline metal or an alkaline earth metal sulfate, chloride, borate, bromide, citrate, acetate or lactate, wherein the average particle size of the cohesive composite particles is from about 0.1 to about 355 microns in diameter.