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US 6,387,391 B1Granted
Bioresorbable polymeric clayey and sticky substance
AssigneeTakiron Co., Ltd.
InventorsYasuo Shikinami, Hiroyuki Kawarada, Chika Nishi
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AssigneeTakiron Co., Ltd.
InventorsYasuo Shikinami, Hiroyuki Kawarada, Chika Nishi
Estimating the term…
This invention provides a claycy and sticky substance as a new biomaterial that cannot be found in the current medical field, which is bioresorbable, shows tackiness, plasticity and shape holding ability at a temperature of approximately from 30 to 40° C. and can give unrestricted shapes at body temperature or more by increasing its fluidity. This clayey and sticky substance comprises a copolymer of two or more bioresorbable monomers, preferably any one of copolymers of p-dioxanone with D-lactic acid, L-lactic acid, D,L-lactic acid, trimethylene carbonate and ε-caprolactone, or a mixture of two or more of these copolymers. This clayey and sticky or clayey substance is suited for a hemostatic material, an adhesive material for tissues, a prosthetic material for tissue reconstruction use, a carrier of drug delivery system, a plugging material, an accretion-preventing material and a scaffold material for tissue engineering use.
A bioresorbable polymeric clayey and sticky substance which comprises at least one copolymer selected from the group consisting of a copolymer of p-dioxanone with D-lactide, which has a weight average molecular weight of from 2,000 to 40,000, a copolymer of p-dioxanone with L-lactide, which has a weight average molecular weight of from 2,000 to 40,000 and a copolymer of p-dioxanone with D, L-lactide, which has a weight average molecular weight of from 3,000 to 50,000, wherein the ratio of p-dioxanone occupying the copolymer is from 50 to 95 mol %, and
A bioresorbable polymeric clayey and sticky substance which comprises at least one copolymer selected from the group consisting of a copolymer of p-dioxanone with D-lactide, which has a weight average molecular weight of from 2,000 to 40,000, a copolymer of dioxanone with L-lactide, which has a weight average molecular weight from 2,000 to 40,000 and a copolymer of p-dioxanone with D,L-lactide, which has a weight average molecular weight of from 3,000 to 50,000, wherein the ratio of p-dioxanone occupying the copolymer is from 50 to 95 mol %, and wherein said substance has not or slight tackiness at a temperature of lower then 30° C., but has tackiness, plasticity and shape holding ability at a temperature of approximately from 30 to 40° C. and can increase its fluidity to give an optional shape at 40° C. or higher.
Dependencies are inferred from the claim text.