Acellular antibordetella vaccine
AssigneeInstitut Pasteur
InventorsPascale Gueirard, Nicole Guiso
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Abstract
The invention relates to an immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (AC-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of Bordetella chosen from B. Tertussis, B. parapertussis or B. bronchiseptica, and in that it comprises, in addition, a bacterial extract containing the expression products of the vrg genes of a strain of Bordetella chosen from B. pertussis, B. parapertussis or B. bronchiseptica, or a portion of these expression products which is sufficient to induce an immune response in a host to which the extract might be administered.
Claims31
An immunogenic composition comprising
- (a) an adenyl cyclase-hemolysin (AC-Hly) protein of a strain of Bordetella selected from the group consisting of B. pertussis, B. parapertussis, and B. bronchiseptica, and
- (b) a bacterial extract containing the expression products of the vrg genes of a strain of Bordetella selected from the group consisting of B. pertussis, B. parapertussis, and B. bronchiseptica, or a portion of these expression products, which is sufficient to induce an immune response in a host.
Dependencies are inferred from the claim text.