Recombinant vaccine containing feline herpes virus type 1 particularly for treating feline infectious peritonitis
AssigneeMerial Limited
InventorsJean-Christophe Francis Audonnet, Philippe Guy Nicolas Baudu, Michel Albert Emile Riviere
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Abstract
The recombinant live vaccine comprises, as vector, a feline herpesvirus comprising and expressing at least one nucleotide sequence encoding a polypeptide, this sequence being inserted into the ORF5 and/or ORF2 sites. Polyvalent vaccine formula and feline herpesvirus DNA fragments.
Claims45
A recombinant feline herpesvirus (FHV) comprising and expressing at least one nucleic acid molecule encoding a polypeptide, wherein the at least one nucleic acid molecule is inserted into the ORF5 and/or ORF2 site of FHV, which in the FHV-1 CO strain, have the nucleotide sequences 5869-7113 and 1665-2596, of SEQ ID NO:
- 1, respectively.
A vaccine comprising a recombinant feline herpesvirus (FHV) comprising and expressing a nucleic acid molecule encoding the VP2 capsid antigen of feline infectious panleukopenia virus.
A vaccine comprising a recombinant feline herpesvirus (FHV) comprising and expressing a nucleic acid molecule encoding the capsid antigen of feline calicivirus, wherein the nucleic acid molecule is inserted into the ORF5 or the ORF2 site of FHV, which, in the FHV-1 CO strain, have the nucleotide sequences 5869-7113 and 1665-2596, of SEQ ID NO:
- 1, respectively.
A vaccine comprising a recombinant feline herpesvirus (FHV) comprising and expressing a nucleic acid molecule encoding an antigen of feline infectious peritonitis virus, wherein the antigen is chosen from among the group consisting of M, modified S, N, 7b and polymerase and wherein the nucleic acid molecule is inserted into the ORF5 or the ORF2 site of FHV, which, in the FHV-1 CO strain, have the nucleotide sequences 5869-7113 and 1665-2596, of SEQ ID NO:
- 1, respectively.
A vaccine comprising a recombinant feline herpesvirus (FHV) comprising and expressing a nucleic acid molecule encoding an antigen of the feline immunodeficiency virus, wherein the antigen is chosen among the group consisting of env, gag and pol, and wherein the nucleic acid molecule is inserted into the ORF5 or the ORF2 site of FHV, which, in the FHV-1 CO strain, have the nucleotide sequences 5869-7113 and 1665-2596, of SEQ ID NO:
- 1, respectively.
A vaccine comprising a recombinant feline herpesvirus (FHV) comprising and expressing a nucleic acid molecule encoding an antigen of feline leukemia virus, wherein the antigen is chosen among the group consisting of env, gag and pol, and wherein the nucleic acid molecule is inserted into the ORF5 or the ORF2 site of FHV, which, in the FHV-1 CO strain, have the nucleotide sequences 5869-7113 and 1665-2596, of SEQ ID NO:1, respectively.
A vaccine comprising a recombinant feline herpesvirus (FHV) comprising and expressing at least one nucleic acid molecule encoding a polypeptide, wherein at least one acid nucleic molecule is inserted into the ORF5 and/or ORF2 site of FHV, which in the FHV-1 CO strain, have the nucleotide sequences 5869-7113 and 1665-2596, of SEQ ID NO:
- 1, respectively.
An immunogenic composition comprising a recombinant feline herpesvirus (FHV) comprising and expressing a nucleic acid molecule encoding the VP2 capsid antigen of feline infectious panleukopenia virus.
An immunogenic composition comprising a recombinant feline herpesvirus (FHV) comprising and expressing a nucleic acid molecule encoding the capsid antigen of feline calicivirus, wherein the nucleic acid molecule is inserted into the ORF5 or the ORF2 site of FHV, which, in the FHV-1 CO strain, have the nucleotide sequences 5869-7113 and 1665-2596, of SEQ ID NO:
- 1, respectively.
An immunogenic composition comprising a recombinant feline herpesvirus (FHV) comprising and expressing a nucleic acid molecule encoding an antigen of feline infectious peritonitis virus, wherein the antigen is chosen among the group consisting of M, modified S, N, 7b and polymerase and wherein the nucleic acid molecule is inserted into the ORF5 or the ORF2 site of FHV, which, in the FHV-1 CO strain, have the nucleotide sequences 5869-7113 and 1665-2596, of SEQ ID NO:
- 1, respectively.
An immunogenic composition comprising a recombinant feline herpesvirus (FHV) comprising and expressing a nucleic acid molecule encoding an antigen of the feline immunodeficiency virus, wherein the antigen is chosen among the group consisting of env, gag and pol, and wherein the nucleic acid molecule is inserted into the ORF5 or the ORF2 site of FHV, which, in the FHV-1 CO strain, have the nucleotide sequences 5869-7113 and 1665-2596, of SEQ ID NO:
- 1, respectively.
An immunogenic composition comprising a recombinant feline herpesvirus (FHV) comprising and expressing a nucleic acid molecule encoding an antigen of feline leukemia virus, wherein the antigen is chosen among the group consisting of env, gag and pol, and wherein the nucleic acid molecule is inserted into the ORF5 or the ORF2 site of FHV, which, in the FHV-1 CO strain, have the nucleotide sequences 5869-7113 and 1665-2596, of SEQ ID NO:1, respectively.
Dependencies are inferred from the claim text.