Use for drug acarbose precose for weight control prevention of weight gain for weight loss for treatment and prevention of obesity

Abstract

Control of weight gain has long been a problem for many people who if they lose weight by dieting often gain it back in a short period of time. Therefore, there has been much research to find a simple means to control weight in humans. Acarbose, an oligosaccharide, is an oral alpha glucosidase inhibitor. The mechanism of action of acarbose results from a competitive inhibition of pancreatic amylase and membrane bound intestinal aplpha-glucoside hydrolase enzymes. Pancreatic alpha amylase hydrolizes complex starches in the lumen of the small intestine. The membrane bound intestinal alpha glucosidases hydrolyze oligo saccharides, trissaccharides and disaccharides to glucose and other monosaccharides in the brush boarder of the small intestines. It has no inhibitory effect against lactase and would therefore not be expected to induce the symptoms of lactose intolerance. The weight gain or loss for an individual is essentially the difference between the calories absorbed and the calories burned.

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