Intraoperative, intravascular and endoscopic tumor and lesion detection, biopsy and therapy
AssigneeImmunomedics, Inc.
InventorMilton David Goldenberg
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Abstract
Methods are provided for close-range intraoperative, endoscopic and intravascular detection and treatment of lesions, including tumors and non-malignant lesions. The methods use antibody fragments or subfragments labeled with isotopic and non-isotopic agents. Also provided are methods for detection and treatment of lesions with photodynamic agents and methods of treating lesions with a protein conjugated to an agent capable of being activated to emit Auger electron or other ionizing radiation. Compositions and kits useful in the above methods are also provided.
Claims9
A method of close-range detection of lesions during an endoscopic, laparoscopic, intravascular catheter, or surgical procedure, wherein the method comprises:
- (a) injecting a patient who is to undergo such a procedure with a bispecific antibody F(ab)2 or F(ab′)2 fragment, wherein the bispecific antibody fragment has a first antibody binding site which specifically binds to an antigen produced or associated with a lesion, and has a second antibody binding site which specifically binds to a hapten, and permitting the antibody fragment to accrete at target sites;
- (b) clearing non-targeted antibody fragments by injecting an amount of a galactosylated anti-idiotype clearing agent sufficient to effect rapid clearance from circulation within about 24 hours of injection, and injecting a bivalent labeled hapten, which quickly localizes at the target site and clears through the kidneys;
- and
- (c) detecting the presence of the hapten by close-range detection of elevated levels of accreted label at the target sites with detection means, within 48 hours of the first injection, and conducting said procedure.
Dependencies are inferred from the claim text.