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US 6,387,329 B1Granted
Use of an array of polymeric sensors of varying thickness for detecting analytes in fluids
AssigneeCalifornia Institute of Technology
InventorsNathan S. Lewis, Erik J. Severin, Michael Freund, Adam J. Matzger
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Abstract
Chemical sensors for detecting the activity of a molecule or analyte of interest is provided. The chemical sensors comprise and array or plurality of sensors that are capable of interacting with a molecule of interest, wherein the interaction provides a response fingerprint. The fingerprint can be associated with a library of similar molecules of interest to determine the molecule's activity and diffusion coefficient.
Claims11
A method of determining the diffusion coefficient of an analyte, comprising:
- contacting a sensor with the analyte, the sensor comprising, regions of a first conductive material and a second material compositionally different than the first material, wherein the sensor provides an electrical path through the regions of the first material and the regions of the second material, and wherein the sensor comprises at least one region of second material having a different thickness than at least one other region of second material, the second material being selected from the group consisting of a conductive organic material, a semi-conductive material and a non-conductive material;
- the sensors constructed to provide a first response when contacted with a first chemical analyte, and a second different response when contacted with a second different chemical analyte;
- and
- measuring a change in the sensor's response to the analyte over time, correlating said response to the value of the diffusion coefficient of the analyte.
1 more element
Dependencies are inferred from the claim text.