Chromatography column
AssigneeWaters Investments Limited
InventorYuri Tuvim
Life of this patent
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Abstract
A chromatography column is disclosed. The large diameter chromatography column comprises a column body with threaded end portions. At each of the end portions, a respective filter housing is disposed. A respective threaded end cap is threaded onto each of the threaded end portions. Each of the end caps has holes for receiving a plurality of mechanical fasteners. The mechanical fasteners are installed into each end cap and apply pressure against the filter housing which forces the filter housing against the face of the column, thus sealing it. When the need to open the column arises, the mechanical fasteners can be easily loosened to release the tension on the thread between column body and end cap. After this, the end cap can be unscrewed with minimal torque.
Claims11
A chromatography column comprising:
- a column body, said column body generally cylindrical in shape and having two open ends, said column body defining a chamber for retaining a chromatography medium, at least one end of said column body having an element for receiving an end cap and a cooperating sealing surface for receiving a sealing surface of a filter housing;
- at least one filter housing disposed at the end of said column body for retaining a chromatography medium within the chamber, said filter housing has an opening and channeling means for directing fluid to the opening and sealing means to seal said member to said column body;
- at least one end cap, said end cap having means for engaging said connecting element of said column body and removable upon rotation, said end cap has a plurality of opening for receiving rods, said plurality of opening having a smaller opening than open end of said column body, said rods having reliably secured to said opening and having at least one end abutting said filter housing to engage said filter housing in a sealing engagement with said column body sealing surface.
In a liquid chromatography system, a chromatography column comprising:
- a column body with at least one threaded end portion;
- at least one filter and distributor member disposed on the end portion of said column body;
- at least one threaded end cap configured to screw on and off of said column body;
- a plurality of holes disposed in said at least one end cap;
- and
- a plurality of mechanical fasteners configured for installing into said plurality of holes, providing a tension release mechanism for releasing tension between threads of the threaded end portion and threads of at least one said threaded end cap created when chromatography medium exerts pressure on said at least one filter and distributor member during operation or packaging of the medium in the column body.
Dependencies are inferred from the claim text.