Method for treating ischemic brain stroke
AssigneeThe Regents of the University of California
InventorJohn G. Frazee
Life of this patent
Estimating the term…
Abstract
Method and apparatus for treating a patient sustaining an acute ischemic stroke in a brain having a blood circulatory system including a torcular Herophili and adjoining transverse venous sinuses, includes steps for partially occluding the sinuses to partially obstruct venous blood drainage while permitting some antegrade venous blood flow from at least one of the sinuses. A flow of the patient's arterial blood is introduced into at least one of the sinuses to produce a continuous retrograde blood flow on the venous side of the brain. In an associated method including a blood pump and occlusion catheters, a heat exchanger is used to lower the temperature of the retrograde blood flow in order to achieve hypothermic treatment of the brain.
Claims31
A method for treating a patient sustaining an acute ischemic stroke in the brain, the brain having a blood circulatory system including a torcular Herophili and first and second transverse venous sinuses adjoining the torcular Herophili, the method comprising at least partially occluding the first and second transverse venous sinuses in first and second locations respectively adjacent to the torcular Herophili to partially obstruct venous blood drainage while permitting some antegrade venous blood flow from at least one of said transverse venous sinuses and introducing a flow of the patient's arterial blood into at least one of said transverse venous sinuses distal to said locations to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow for a period of time until the patient exhibits at least some resolution of ischemic brain symptoms.
A method for treating a patient undergoing brain aneurysm clipping and brain tumor resection requiring arterial inflow occlusion, the brain having a blood circulatory system including a torcular Herophili and first and second transverse venous sinuses adjoining the torcular Herophili, the method comprising at least partially occluding the first and second transverse venous sinuses in first and second locations respectively, adjacent to the torcular Herophili to partially obstruct venous blood drainage while permitting some antegrade venous blood flow from at least one of said transverse venous sinuses and introducing a flow of the patient's arterial blood into at least one of said transverse venous sinuses distal to said locations to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow for a period of time until the arterial inflow occlusion is relieved.
A method for treating a patient sustaining a non-hemorrhagic angiographic injury in the brain, the brain having a blood circulatory system including a torcular Herophili and first and second transverse venous sinuses adjoining the torcular Herophili, the method comprising at least partially occluding the first and second transverse venous sinuses in first and second locations respectively, adjacent to the torcular Herophili to partially obstruct venous blood drainage while permitting some antegrade venous blood flow from at least one of said transverse venous sinuses and introducing a flow of the patient's arterial blood into at least one of said transverse venous sinuses distal to said locations to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow for a period of time until the patient exhibits at least some resolution of brain injury symptoms.
A method for treating a patient sustaining an acute ischemic stroke in the brain, the brain having a blood circulatory system comprising a torcular Herophili, first and second transverse venous sinuses adjoining the torcular Herophili, the patient having first and second venous vessels remote from the brain, by the use of first and second balloon catheters having proximal and distal extremities and having inflatable balloons on the distal extremities, the method comprising introducing the distal extremity of the first balloon catheter into the first vessel and thence into the first transverse venous sinus into close proximity to the torcular Herophili, introducing the distal extremity of the second balloon catheter into the second vessel and thence into the second transverse venous sinus into close proximity to the torcular Herophili, inflating the balloons of the first and second balloon catheters to at least partially occlude the first and second transverse sinuses while permitting antegrade flow from at least one of the transverse venous sinuses to prevent excessive pressure buildup in the transverse venous sinus, introducing a flow of the patient's arterial blood into at least one of the transverse venous sinuses distal to the balloon positioned in that transverse venous sinus to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow, for a period of time up to when the patient exhibits resolution of at least some of the ischemic brain symptoms.
A method for the hypothermic treatment of a patient having a body with a brain and other body organs, the body having a normal body temperature, including the steps of:
- providing a source of blood;
- pumping the blood from the source;
- during the pumping step cooling the blood;
- and
- introducing the cooled blood retrograde directly into the brain in order to lower the normal body temperature of only the brain of the patient.
An apparatus for the hypothermic treatment of a patient having a body with a brain and other body organs, the apparatus comprising:
- a source of autologous blood;
- a blood pump for drawing the blood from the source and for producing blood under pressure for delivery to the brain;
- a heat exchanger for reducing the temperature of the blood to produce cooled blood under pressure;
- and
- a catheter for introducing the cooled blood under pressure into the venous system of only the brain of the patient.
Dependencies are inferred from the claim text.