Suppository form comprising an acid-labile active compound
AssigneeByk Gulden Lomberg Chemische Fabrik GmbH
InventorsRudolf Linder, Rango Dietrich
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Abstract
Acid-labile active compounds are prepared in suppository form, particularly for rectal administration.
Claims29
A suppository for an acid-labile active compound wherein the acid-labile compound is an acid-labile proton pump inhibitor, a salt of an acid-labile proton pump inhibitor with a base or a hydrate of a salt of an acid-labile proton pump inhibitor with a base comprising at least one pharmaceutical auxiliary and a plurality of individual active compound units, wherein the acid-labile active compound in each individual active compound unit is surrounded by a mixture of at least one sterol and at least one polymer, by at least one fatty alcohol or by a mixture of at least one fatty alcohol and at least one polymer and/or at least one sterol.
A suppository comprising an acid labile proton pump inhibitor, at least one sterol and at least one polymer obtainable by spray-drying a suspension of the acid-labile proton pump inhibitor in a solution of the sterol and the polymer in a suitable solvent.
A suppository comprising an acid-labile proton pump inhibitor and
- a) at least one fatty alcohol obtainable by spray congealing a suspension of the acid-labile compound in the fatty alcohol, or
- b) a mixture of at least one fatty alcohol and at least one polymer obtainable by spray congealing a suspension of the acid-labile compound in a solution of the polymer in the fatty alcohol, or
- c) a mixture of at least one fatty alcohol and at least one sterol obtainable by spray congealing a suspension of the acid-labile compound in a solution of the sterol in the fatty alcohol, or
- d) a mixture of at least one fatty alcohol, at least one polymer and at least one sterol obtainable by spray congealing a suspension of the acid-labile compound in a solution of the polymer and sterol in the fatty alcohol.
Dependencies are inferred from the claim text.