Asymmetric synthesis catalyzed by transition metal complexes with rigid chiral ligands
AssigneeThe Penn State Research Foundation
InventorXumu Zhang
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Abstract
This invention is to develop novel transition metal catalysts for the practical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity.
Claims10
A chiral ligand having restricted conformational flexibility, wherein said ligand is chosen from enantiomers of substituted or unsubstituted (2,2′)-bis(diarylphosphinoxy)-(1,1′)-dicyclo compounds and enantiomers of substituted or unsubstituted (2,2′)-bis(diarylphosphinoxy)-(1,1′)-dicyclo compounds, and wherein said ligand has saturated carbons at the 2, 2′, 1, and 1′ positions.
Dependencies are inferred from the claim text.