Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics
AssigneeGenome Therapeutics Corporation
InventorsLynn A. Doucette-Stamm, David Bush
Life of this patent
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Abstract
The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
Claims10
An isolated nucleic acid comprising a nucleotide sequence encoding a S. epidermis polypeptide selected from the group consisting of SEQ ID NO:
- 2992, SEQ ID NO:
- 3209, SEQ ID NO:
- 4536, SEQ ID NO:
- 4728, SEQ ID NO:
- 4737, SEQ ID NO:
- 5089, SEQ ID NO:
- 5172, SEQ ID NO:
- 5318, and SEQ ID NO:
- 5510.
An isolated nucleic acid comprising a nucleotide sequence encoding a S. epidermis polypeptide or fragment thereof, said nucleic acid selected from the group consisting of SEQ ID NO:
- 155, SEQ ID NO:
- 372, SEQ ID NO:
- 1699, SEQ ID NO:
- 1891, SEQ ID NO:
- 1900, SEQ ID NO:
- 2252, SEQ ID NO:
- 2335, SEQ ID NO:
- 2481, and SEQ ID NO:
- 2673.
A probe comprising a nucleotide sequence consisting of at least 40 nucleotides of a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 155, SEQ ID NO:
- 372, SEQ ID NO:
- 1699, SEQ ID NO:
- 1891, SEQ ID NO:
- 1900, SEQ ID NO:
- 2252, SEQ ID NO:
- 2335, SEQ ID NO:
- 2481, and SEQ ID NO:
- 2673.
An isolated nucleic acid comprising a nucleotide sequence of at least 40 nucleotides in length, wherein the sequence is hybridizable to a nucleic acid having a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 155, SEQ ID NO:
- 372, SEQ ID NO:
- 1699, SEQ ID NO:
- 1891, SEQ ID NO:
- 1900, SEQ ID NO:
- 2252, SEQ ID NO:
- 2335, SEQ ID NO:
- 2481, and SEQ ID NO:
- 2673.
Dependencies are inferred from the claim text.