Glucocorticoid receptor modulators

A compound of formula II

• an isomer thereof, a prodrug of said compound or isomer, or a pharmaceutically acceptable salt of said compound, isomer or prodrug;
• wherein
• R1 is -phenyl substituted with zero or one of the following:
• —OH, —NR12R13, —NR12—C(O)—(C1-C4)alkyl, —CN, —(C0-C2)alkyl-het, —O—(C1-C3)alkyl-C(O)—NR12R13, —NR12—(C0-C2)alkyl-C(O)—NR12R13, —(C0-C2)alkyl-NR12—SO2—R13, —NR12—SO2—het, —O—C(O)—(C1-C4)alkyl or —O—SO2—(C1-C4)alkyl;
• R2 is —OH;
• R3 is a) —(C1-C6)alkyl substituted with 0 or 1 of the following:
• —CF3, —CN, —(C3-C6)cycloalkyl, -phenyl or —N3, b) —C≡C— substituted with 1 of the following:
• —(C1-C5)alkyl, —Cl, —CF3, —(C3-C6)cycloalkyl, -phenyl or -benzyl:
• c) —CH2OH, d) —CH2O(C1-C5)alkyl wherein 1 carbon atom, other than the connecting carbon atom, may optionally be replaced with 1 oxygen atom, e) —CH2O(C2-C5)alkenyl, f) —CH2O(C2-C5)alkynyl wherein 1 carbon atom, other than the connecting carbon atom, may optionally be replaced with 1 oxygen atom, g) —CH2ORy, h) —CN or i) —CF3;
• wherein
• Ry is a) —(C1-C3)alkyl-CF3, b) —(C3-C6)cycloalkyl, c) -phenyl or d) -benzyl;
• R10 is —C(O)—NH—Z—het;
• het is a 5-, 6- or 7-membered saturated, partially saturated or unsaturated ring containing from one (1) to three (3) heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulfur;
• and substituted with 0 to 3 Rx;
• Rx for each occurrence is independently a) -halo, b) —OH, c) —(C1-C8)alkyl, d) —(C2-C6)alkenyl, e) —(C2-C6)alkynyl, f) —O(C1-C6)alkyl, g) —O(C2-C6)alkenyl, h) —O(C2-C6)alkynyl, i) —(C0-C6)alkyl-NR12R13, j) —C(O)—NR12R13, k) —(C0-C2)alkyl-SO2R12, l) —(C0-C2)alkyl-SOR12, m) —(C0-C2)alkyl-SR12, n) —NR12—SO2R13, o) —NR12—C(O)—R13, p) —NR12—OR13, q) —SO2—NR12R13, r) —CN, s) —CF3, t) —C(O)(C1-C6)alkyl, u) ═O or v) —(C0-C2)alkyl-SO2-phenyl;
• Z is —(C1-C2)alkyl;
• R12 and R13 are independently a) —H or b) —(C1-C4)alkyl.