Compositions and methods for detecting adult Taenia solium
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsVictor C. W. Tsang, Patricia P. Wilkins, James C. Allan
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Abstract
Compositions and methods for the detection of adult Taenia solium and the diagnosis and treatment of T. solium infection are described. The compositions contain one or more adult T. solium polypeptides. The polypeptides are useful as diagnostic agents for the detection of adult tapeworm infection. More preferably, the polypeptides are T. solium glycoprotein antigens referred to herein as T. solium excretory/secretory (TS/ES) polypeptides. The most preferred TS/ES polypeptide has a molecular weight of approximately 33 kDa, 38 kDa, or 42 kDa as determined by SDS-PAGE analysis.
Claims29
A method for distinguishing an adult Taenia solium (T. solium) infection from a larval T. solium infection in a subject comprising:
- contacting a biological sample from the subject with an isolated, adult-specific T. solium excretory/secretory polypeptide;
- and
- detecting binding of the isolated, adult-specific T. solium excretory/secretory polypeptide to an adult-specific T. solium excretory/secretory polypeptide antibody in the sample, wherein presence of binding is indicative of the presence of adult T. solium infection in the subject.
A method for distinguishing an adult T. solium infection from a larval T. solium infection in a subject, comprising:
- contacting a biological sample from the subject with an adult-specific T. solium excretory/secretory polypeptide antibody;
- and
- detecting binding of the adult-specific T. solium excretory/secretory polypeptide antibody to an adult-specific T. solium excretory/secretory polypeptide in the biological sample from the subject, wherein presence of binding is indicative of the presence of adult T. solium infection in the subject.
Dependencies are inferred from the claim text.