Process for producing trifluoromethylbenzylamines
AssigneeCentral Glass Company, Limited
InventorsSatoru Narizuka, Eri Tsukada, Takashi Kume
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Abstract
The present invention relates to a process for producing a trifluoromethylbenzylamine represented by the general formula (1), where R1 represents hydrogen atom, a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine, or trifluoromethyl group. This process includes the step of reducing an oxime by hydrogen in an organic solvent in the presence of a catalyst and ammonia. The oxime is represented by the general formula (2), where R1 is defined as above, and R2 represents hydrogen atom, an alkyl group or an aralkyl group. With this process, the trifluoromethylbenzylamine can be produced with high yield.
Claims11
A process for producing a trifluoromethylbenzylamine represented by the general formula (1), said process comprising reducing an oxime by hydrogen in an organic solvent in the presence of a catalyst and ammonia, said oxime being represented by the general formula (2),
- where R1 represents hydrogen atom, a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine, or trifluoromethyl group,
- where R1 is defined as above, and R2 represents hydrogen atom, an alkyl group or an aralkyl group.
A process for producing a trifluoromethylbenzylamine represented by the general formula (1), said process comprising:
- (a) reacting a trifluoromethylbenzaldehyde represented by the general formula (2) with a hydroxylamine represented by the general formula (3), thereby obtaining an oxime represented by the general formula (4);
- and
- (b) reducing said oxime by hydrogen in an organic solvent in the presence of a catalyst and ammonia, thereby producing said trifluoromethylbenzylamine,
- where R1 represents hydrogen atom, a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine, or trifluoromethyl group,
- where R1 is defined as above,
- H2NOR2 (3)
- where R2 represents hydrogen atom, an all group or an aralkyl group,
- where R1 and R2 are defined as above.
A process for producing a trifluoromethylbenzylamine represented by the general formula (1), said process comprising:
- (a) mixing together a trifluoromethylbenzaldehyde represented by the general formula (2), an acid salt of a hydroxylamine represented by the general formula (3), and a base, thereby obtaining an oxime represented by the general formula (4);
- and
- (b) reducing said oxime by hydrogen in an organic solvent in the presence of an catalyst and ammonia, thereby producing said trifluoromethylbenzylamine,
- where R1 represents hydrogen atom, a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine, or trifluoromethyl group,
- where R1 is defined as above,
- H2NOR2 (3)
- where R2 represents hydrogen atom, an akyl group or an aralkyl group,
- where R1 and R2 are defined as above.
Dependencies are inferred from the claim text.