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AssigneePeptide Technology Limited
InventorsAntonio Ferrante, Alfred Poulos, Christopher John Easton, Michael Joseph Pitt, Thomas Alistair Robertson, Deborah Ann Rathjen
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The present invention provides polyunsaturated fatty acid compounds having antimalarial and/or neutrophil stimulatory activity. The polyunsaturated fatty acids contain 18-25 carbons and 1-6 double bonds and are characterized in that they have one or two substitutions selected from the group consisting of β oxa, γ oxa, β thia and γ thia. It is also preferred that the polyunsaturated fatty acid compound includes a further substitution selected from the group consisting of hydroxy, hydroperoxy, peroxy, carboxymethyl substitutions or attached to an amino acid. The invention also provides a method of producing an unsaturated oxa substituted fatty acid comprising reacting an unsaturated fatty acid alcohol with a carbene that is inserted in the OH bond of the alcohol, the invention further provides a method of treating inflammation with a composition comprising at least one hydroxy, hydroperoxy or peroxy derivative of a polyunsaturated fatty acid having a C18-24 carbon chain and 1-6 cis or trans double bonds.
A polyunsaturated fatty acid compound having antimalarial and/or neutrophil stimulatory activity, the polyunsaturated fatty acid containing 18-25 carbons and 1-6 double bonds and wherein the polyunsaturated fatty acid compound has one or two substitutions selected from the group consisting of β oxa, γ oxa, β thia and γ thia.
A method of producing an unsaturated oxa substituted fatty acid comprising reacting an unsaturated fatty acid alcohol with a carbene such that the carbene is inserted in the O—H bond of the alcohol.
A method of treating inflammation in a subject, the method comprising administering to the subject a therapeutically effective amount of an anti-inflammatory composition comprising at least one hydroxy, hydroperoxy, or peroxy derivative of a polyunsaturated fatty acid having a carbon chain of 18 to 24 carbon atoms and having 1-6 cis or trans double bonds.
Dependencies are inferred from the claim text.