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US 6,376,687 B1Granted
Steroid sulfatase inhibitors and methods for making and using the same
AssigneesDuquesne University of the Holy Ghost, Kyowa Hakko Kogyo Co., Ltd.
InventorsPui-Kai Li, Chikara Murakata, Shiro Akinaga
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Abstract
Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic treatment of a patient are also disclosed.
Claims9
A compound having the formula:
- wherein X and Y are both carbons and the bond between X and Y is either single or double;
- wherein R1 and R2 are independently selected from hydrogen and a lower alkyl group having one to six carbons;
- and
- R3 is:
- R4 and R5 are independently selected from straight or branched chain alkyl groups having one to fourteen carbons, and straight or branched chain alkoxy groups having one to six carbons.
2 more elements
Dependencies are inferred from the claim text.