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US 6,376,515 B2Granted
Benzamides and related inhibitors of factor Xa
AssigneeCOR Therapeutics, Inc.
InventorsBing-Yan Zhu, Penglie Zhang, Lingyan Wang, Wenrong Huang, Erick A. Goldman, Wenhao Li, Jingmei Zuckett, Yonghong Song, Robert M. Scarborough
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Abstract
Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
Claims72
A compound of formula VI:
- wherein:
- Z′ and Z″ are each independently a C1-C6 alkyl which is optionally substituted with a hydroxyl, carboxylic acid or carboxylic acid ester group;
- R1a is a member selected from the group of H, —F, —Cl and Br;
- R1d2 and R1d4 are each H;
- R1d1 and R1d3 are each independently a member selected from the group of H, —Cl, —F, —Br, —OH and —OMe;
- R1e is a member selected from the group of —F, —Cl, —Br, —OH, —Me and —OMe,
- and all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives thereof.
4 more elements
A compound formula VII:
- wherein:
- A-Q is a member selected from the group of:
- where Z′ is a C1-C6 alkyl which is optionally substituted with a hydroxyl, carboxylic acid or carboxylic acid ester group;
- R1a is a member selected from the group of H, —F, —Cl and Br;
- R1d2 and R1d4 are each H;
- R1d1 and R1d3 are each independently a member selected from the group of H, —Cl, —F, —Br, —OH and —OMe;
- R1e is a member selected from the group of —F, —Cl, —Br, —OH, —Me and —OMe;
- and all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives thereof.
5 more elements
Dependencies are inferred from the claim text.