Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
AssigneeControl Delivery Systems, Inc.
InventorsHong Guo, Paul Ashton
Life of this patent
Estimating the term…
Abstract
A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.
Claims40
A sustained release drug delivery system comprising:
- an inner drug core comprising a therapeutically effective amount of an agent effective in obtaining a desired local or systemic physiological or pharmacological effect;
- an inner tube impermeable to the passage of said agent, said inner tube having first and second ends and covering at least a portion of said inner drug core, said inner tube sized and formed of a material so that said inner tube is dimensionally stable to accept said drug core without changing shape;
- an impermeable member positioned at said inner tube first end, said impermeable member preventing passage of said agent out of said drug core through said inner tube first end;
- and
- a permeable member positioned at said inner tube second end, said permeable member allowing diffusion of said agent out of said drug core through said inner tube second end.
A method of manufacturing a sustained drug delivery system, comprising the steps of:
- positioning a drug core in a tube, said drug core containing a therapeutically effective amount of an active agent;
- and
- positioning an end member to said tube to form a closed-end tube, said end member selected from the group consisting of an impermeable cap and a permeable plug.
Dependencies are inferred from the claim text.