Calcium phosphate cements prepared from silicate solutions
OwnerBrent R. Constantzinventor
Life of this patent
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Abstract
Methods are provide for producing flowable compositions, e.g. pastes, that set into calcium phosphate products. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a solution of a soluble silicate, e.g. sodium silicate, and the combined liquids and solids are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g. bone defects.
Claims35
A method or producing a flowiable composition that sets into a solid calcium phosphate containing product in an in vivo fluid environment, said method comprising:
- combining:
- (a) a silicate solution containing a soluble silicate;
- and
- (b) dry reactants comprising a calcium source and a phosphate source, wherein said silicate solution and dry reactants are combined in a ratio sufficient to produce a flowable material that sets in an in vivo fluid environment in less than 20 minutes into a solid calcium phosphate containing product having a compressive strength of at least about 20 MPa upon reaction of said calcium and phosphate sources and said soluble silicate.
A method of producing a paste that sets into a solid calcium phosphate containing product in an in vivo fluid environment, said method comprising:
- (a) combining:
- (i) dry reactants comprising a calcium source and a phosphate source;
- and
- (ii) a solution of a soluble silicate having a concentration ranging from about 5% to 10%, wherein said dry reactants and said solution are combined in a ratio sufficient to provide for said paste;
- and
- (b) mixing said combined reactants and solution for a sufficient period of time to produce a paste that sets in an in vivo fluid environment in less than 20 minutes into a solid calcium phosphate containing product having a compressive strength of at least about 20 MPa upon reaction of said calcium and phosphate sources and said soluble silicate.
A flowable composition that sets into a solid calcium phosphate contain product in an in vivo fluid environment, wherein said composition is produced by the method comprising:
- combining dry reactants comprising a source of calcium and phosphate with a solution of a soluble silicate;
- and
- mixing said combined dry reactants and solution for a period of time sufficient to produce said flowable product that sets in an in vivo fluid environment in less than 20 minutes into a solid calcium phosphate containing product having a compressive strength of at least about 20 MPa upon reaction of said calcium and phosphate sources and said soluble silicate.
A kit for use in a preparing a flowable composition that sets in an in vivo fluid environment into a calcium phosphate product, said kit comprising:
- (a) dry reactants comprising a calcium source and a phosphate source that produce a flowable composition upon combination with a solution of a soluble silicate, wherein said flowable composition sets in an in vivo fluid environment in less than 20 minutes into a solid calcium phosphate containing product having a compressive strength of at least about 20 MPa upon reaction of said calcium and phosphate sources;
- and
- (b) a solution of a soluble silicate.
A method of repairing a hard tissue defect, said method comprising:
- applying to the site of said defect a flowable composition that sets in an in vivo fluid environment into a solid calcium phosphate containing product, wherein said composition is produced by the method comprising:
- (a) combining dry reactants comprising a source of calcium and phosphate with a solution of a soluble silicate;
- and
- (b) mixing said combined dry reactants and solution for a period of time sufficient to produce said flowable product that sets in an in vivo fluid environment in less than 20 minutes into a solid calcium phosphate containing product having a compressive strength of at least about 20 MPa upon reaction of said calcium and phosphate sources and said soluble silicate.
A packaged calcium phosphate cement, said packaged cement comprising:
- a tubular element separated into first and second compartments by a removable barrier;
- dry reactants comprising a source of calcium and phosphate present in said first compartment that produce a flowable composition upon combination with a solution of a soluble silicate, wherein said flowable composition sets in an in vivo fluid environment in less than 20 minutes into a solid calcium phosphate containing product having a compressive strength of at least about 20 MPa upon reaction of said calcium and phosphate sources;
- and
- a solution of a soluble silicate present in said second compartment.
A method of producing a flowable composition that sets in an in vivo fluid environment into a said calcium phosphate containing product, said method comprising:
- combining:
- (a) a silicate solution containing a soluble silicate;
- and
- (b) dry reactants comprising a calcium source and a phosphate source, wherein said silicate solution and dry reactants are combined in a ratio sufficient to produce a flowable material that sets in an in vivo fluid environment in less than 20 minutes into a solid calcium phosphate containing product having a compressive strength of at least about 20 MPa upon reaction of at least said calcium and phosphate sources.
Dependencies are inferred from the claim text.