Labelled elastase inhibitors
AssigneeAmersham International plc
InventorsKaren Jane Barnes, Gary Robert Bower, Alan Michael Forster, Peter Knox, Marivi Mendizabal, Anthony Eamon Storey
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Abstract
A human leucocyte elastase (HLE) inhibitor labelled with a detector moiety where the inhibitor is synthetic and has a molecular weight of less than 2000, is useful for the diagnostic imaging of sites of inflammation of infection in vivo, for labelling leucocytes in vitro, or for radiotherapy of rthritis. The HLE inhibitor is preferably a β-lactam or an azetidinone.
Claims14
A human leucocyte elastase (HLE) inhibitor labelled with a detectable moiety where the inhibitor is synthetic and has a molecular weight of less than 2000, and the detectable moiety is chosen from the group consisting of a radioactive isotope, a paramagnetic ion, a radiopaque compound and an ultrasound contrast agent.
Dependencies are inferred from the claim text.