Polyethylene glycol coating for electrostatic dry deposition of pharmaceuticals
AssigneeOrtho-McNeil Pharmaceutical, Inc.
InventorsShifeng Bill Wei, Herling Uang
Life of this patent
Estimating the term…
Abstract
The invention relates to a substrate coating for the electrostatic deposition of dry powder medicaments for use in the manufacture of pharmaceutical dosage forms comprising micronized polyethylene glycol (PEG), with A molecular weight in the range of 1,000 to 20,000, and having a particle size of 1-100 μm. The invention also relates to pharmaceutical compositions having such a substrate coating, and processes for manufacturing such pharmaceutical compositions. The invention also relates to the technology of reversing negative charge of medicaments so that they can be electrostatically deposited on a negatively charged substrate.
Claims8
A pharmaceutical composition comprising an edible substrate having micronized drug substance with a particle size of 1-100 μm deposited on the surface of the substrate by electrostatic dry powder deposition, and a film coating on the substrate and drug substance consisting essentially of polyethylene glycol, wherein the film coating is applied by:
- (a) coating the substrate in place by electrostatic dry powder deposition with dry micronized polyethylene glycol having a molecular weight in the range of 1,000 to 20,000 and having a particle size of 1-100 μm, and
- (b) melting the dry polyethylene glycol coating and allowing it to cool whereupon a protective coating is formed.
Dependencies are inferred from the claim text.