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US 6,371,992 B1Granted
Acellular matrix grafts: preparation and use
AssigneeThe Regents of the University of California
InventorsEmil A. Tanagho, Rajvir Dahiya, Tom F. Lue, Gerald R. Cunha
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Abstract
Acellular matrix grafts are provided with are isolated from natural sources and consist essentially of a collagen and elastin matrix which is devoid of cellular components. The grafts are useful scaffolds which promote the regeneration of muscle tissue and aid in restoring muscle function. Due to their acellular nature, the grafts lack antigenicity. As a result, the acellular matrix grafts can be isolated from autographic, allographic or xenographic tissues.
Claims10
An insoluble elastic matrix graft for repairing bladder smooth muscle having the following properties:
- (i) the matrix graft is derived from bladder smooth muscle tissue;
- (ii) the matrix graft is impermeable to urine;
- (iii) the matrix graft consists essentially of an intact framework of collagen and elastic fibers that is free of cell contents;
- and,
- (iv) the framework permits growth of muscle cells within the framework.
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