Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
AssigneeNeoMend, Inc.
InventorsGregory M Cruise, Olexander Hnojewyj
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Abstract
A biocompatible and biodegradable barrier material is applied to a tissue region, e.g., to seal a vascular puncture site. The barrier material comprises a compound, which is chemically cross-linked without use of an enzyme to form a non-liquid mechanical matrix. The compound preferably includes a protein comprising recombinant or natural serum albumin, which is mixed with a polymer that comprises poly(ethylene) glycol (PEG), and, most preferably, a multi-armed PEG polymer.
Claims9
A biocompatible and biodegradable material applied to seal a vascular puncture comprising a mixture of buffered protein solution having a pH value of between about 7 and about 10 and comprising recombinant or natural human serum albumin at a concentration of about 25% or less, and a polymer solution comprising poly(ethylene glycol)(PEG) with a functionality of at least three, wherein, upon mixing, the buffered protein solution and the polymer solution cross-link to form a solid matrix that seals the vascular puncture without use of a photo-initiator and ultraviolet light energy.
Dependencies are inferred from the claim text.