Treatment of mastitis
AssigneeEli Lilly and Company
InventorKarl Robert Dahnke
Life of this patent
Estimating the term…
Abstract
The invention provides new fluorinated cephalosporin antibiotics of Formula I wherein Ra, Rb, Rc, Rd and Re, independently, are H, F or a C1-C6 alkyl-(Z)n— group having at least one fluorine substituent; X is O or S; Y is S, O, or —CH2—; Z is O, S, —SO—, or —SO2—; m and n independently are 0 or 1; and R1 is H, C1-C6-alkyl, phenyl or benzyl, each of which may optionally have up to three substituents selected from halo, C1-C4-alkoxy, phenyl, NO2, C1-C6-alkanoyl, benzoyl, or C1-C6-alkanoyloxy; or a physiologically acceptable salt thereof; and methods of preventing or treating or treating infection, particularly mastitis in ruminants, using these antibiotics.
Claims21
A compound of the formula
- wherein
- Ra, Rb, Rc, Rd and Re, independently, are H, F or a C1-C6 alkyl-(Z)n— group having at least one fluorine substituent;
- Z is O, S, —SO—, or —SO2—;
- m and n independently are 0 or 1;
- and
- R1 is H, C1-C6-alkyl, phenyl or benzyl, each of which may optionally have up to three substituents selected from halo, C1-C4-alkoxy, phenyl, NO2, C1-C6-alkanoyl, benzoyl, or C1-C6-alkanoyloxy;
- or a physiologically acceptable salt thereof;
- provided that:
- 1) at least one of Ra, Rb, Rc, Rd or Re is other than hydrogen;
- and
- 2) when Rc is F, or one of Rb or Rd is CF3, at least one of the remaining Ra, Rb, Rc, Rd or Re is other than hydrogen.
A compound of the formula:
- wherein
- Ra, Rb, Rd and Re, independently, are H, F or a C1-C6 alkyl-(Z)n— group having at least one fluorine fluorine substituent;
- Rc is a C1-C6 alkyl-(Z)n—group having at least one substituent;
- Z is O, S, —SO—, or —SO2—;
- n is O or 1;
- and
- R1 is H, C1-C6-alkyl, phenyl or benzyl, each of which may optionally have up to three substituents selected from halo, C1-C4-alkoxy, phenyl, NO2, C1-C6-alkanoyl, benzoyl, or C1-C6-alkanoyloxy;
- or a physiologically acceptable salt thereof.
Dependencies are inferred from the claim text.