Aldolase catalytic antibody
AssigneeThe Scripps Research Institute
InventorsCarlos F. Barbas, III, Richard A. Lerner, Juergen Wagner
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Abstract
Antibodies that catalyze the aldol reaction are generated by immunization with a reactive compound that covalently traps a Lysine (Lys) residue in the binding pocket of the antibody by formation of a stable vinylogous amide, i.e., a covalent antibody/hapten complex. The resultant catalytic antibodies employ a catalytic mechanism which mimics the catalytic mechanism employed by natural class I aldolase enzymes.
Claims8
A solution for catalyzing a reaction between reactants, the solution comprising a solvent and a catalyst, said catalyst being selected from the group consisting of a catalytic antibody and a catalytic molecule containing a combining site portion of said catalytic antibody, said solvent and said catalyst being combined with one another, said solvent being suitable for dissolving said reactants and for promoting the catalysis of the reaction, said catalyst being of a type which forms a complex during catalysis, said complex being selected from the group consisting of a stable covalent vinylogous amide, a conjugated enamine, and a Schiff base.
Dependencies are inferred from the claim text.