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US 6,365,416 B1Granted
Method of preparing delta-9-tetrahydrocannabinol
AssigneeThe University of Mississippi
InventorsMahmoud A. Elsohly, Samir A. Ross
Life of this patent
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Abstract
A method of preparing THC using extraction of plant material with a non-polar solvent followed by vacuum distillation and chromatography.
Claims11
A method for the isolation of delta-9-tetrahydrocannabinol (THC) from cannabis plant material in large-scale quantities comprising:
- a) extracting the Cannabis plant material with a non-polar organic solvent to form an extract;
- b) removing the solvent from the extract to give an extract residue;
- c) optionally, subjecting the extract residue to column chromatography to give a residue eluate;
- d) subjecting one of the extract residue or the residue eluate provided by column chromatography to a first low pressure flash distillation and collecting a first distillate containing THC from a constant boiling range in the distillation;
- e) optionally, subjecting the first distillate to a second low pressure flash distillation to give a second distillate containing THC;
- and
- f) subjecting one of the first distillate obtained from the first flash distillation or the second distillate obtained from the second flash distillation to at least one of column chromatography, normal HPLC, or reversed HPLC to provide a product containing delta-9-tetrahydrocannabinol.
4 more elements
A method for the isolation of delta-9-tetrahydrocannabinol (THC) from cannabis plant material in large-scale quantities comprising:
- a) extracting the Cannabis plant material with a non-polar organic solvent to form an extract;
- b) removing the solvent from the extract to give an extract residue;
- c) subjecting the extract residue to column chromatography to give a residue eluate;
- d) subjecting the residue eluate provided by column chromatography to a first low pressure flash distillation and collecting a first distillate containing THC from a constant boiling range in the distillation;
- e) optionally, subjecting the first distillate to a second low pressure flash distillation to give a second distillate containing THC;
- and
- f) subjecting one of the first distillate obtained from the first flash distillation or the second distillate obtained from the second flash distillation to at least one of column chromatography, normal HPLC, or reversed HPLC to provide a product containing delta-9-tetrahydrocannabinol.
4 more elements
A method for the isolation of delta-9-tetrahydrocannabinol (THC) from cannabis plant material in large-scale quantities comprising:
- a) extracting the Cannabis plant material with a non-polar organic solvent to form an extract;
- b) removing the solvent from the extract to give an extract residue;
- c) subjecting the extract residue to column chromatography to give a residue eluate;
- d) subjecting the residue eluate provided by column chromatography to a first low pressure flash distillation and collecting a first distillate containing THC from a constant boiling range in the distillation;
- e) subjecting the first distillate to a second low pressure flash distillation to give a second distillate containing THC;
- and
- f) subjecting the second distillate obtained from the second flash distillation to at least one of column chromatography, normal HPLC, or reversed HPLC to provide a product containing delta-9-tetrahydrocannabinol.
4 more elements
Dependencies are inferred from the claim text.