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US 6,365,208 B1Granted
Stable lactase tablets
AssigneeMcNeil-PPC, Inc.
InventorsSunanda R. Kulkarni, Robert T. McFadden, David H. Rogers, James T. Walter, Jr.
Life of this patent
Estimating the term…
Abstract
There is a formulation having improved chemical stability containing: a) from about 1% to about 20% by weight of a combination of lactase and cutting agent where said combination has from 0 to about 4 parts by weight cutting agent for each part by weight lactase; b) from about 1% to about 98% by weight of microcrystalline cellulose; c) from about 0% to about 97% by weight of mannitol; and d) an effective amount of lubricant to aid compression.
Claims11
A formulation comprising:
- a) from about 9.6 to about 12 weight percent lactase mixture;
- said lactase mixture contains about 50% lactase;
- b) about 30 weight percent microcrystalline cellulose;
- c) from about 57 to about 59.4 weight percent mannitol;
- d) an effective amount of lubricant to aid compression;
- wherein about at least about 81% of the initial lactase is present after storage after 6 months at 35° C.
3 more elements
A formulation comprising:
- a) from about 3000 to about 9000 FCC lactase units;
- b) about 30 weight percent microcrystalline cellulose;
- c) from about 57 to about 59.4 weight percent mannitol.
Dependencies are inferred from the claim text.