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US 6,365,190 B1Granted
Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
AssigneeInhale Therapeutic Systems
InventorsMarc S. Gordon, Andrew Clark, Thomas K. Brewer
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Abstract
Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions of the components and spray drying them simultaneously in a spray dryer. The hydrophilic and hydrophobic component are separately dissolved in separate solvents and directed simultaneously through a nozzle, usually a coaxial nozzle, into the spray dryer. The method provides dry powders having relatively uniform characteristics.
Claims18
A method for preparing a dry powder composition, said method comprising:
- preparing an aqueous solution of a hydrophilic component;
- preparing an organic solution of a hydrophobic component in an organic solvent;
- delivering the aqueous solution containing the hydrophilic component to an atomizer;
- delivering the organic solution containing the hydrophobic component to the atomizer separately from the aqueous solution containing the hydrophilic component;
- atomizing the two solutions together in the atomizer to produce droplets containing both components;
- and
- flowing the droplets of the aqueous solution and the organic solution in a heated gas stream to form dry particles comprising a mixture of the hydrophilic and hydrophobic components, said particles having a size distribution wherein at least 85% of the particles by weight comprise particles having an average size in the range from 0.4-5 μm.
4 more elements
Dependencies are inferred from the claim text.