Self-destructing, controlled release peroral drug delivery system

A method of making an oral tablet for delivering a beneficial agent to a mammal, comprising the steps of:

• forming a core compartment having a beneficial agent;
• and
• surrounding the core compartment with a unitary self-destructing shell, the self-destructing shell comprising a plurality of disintegrant particles dispersed within a semipermeable matrix.

The method of making an oral tablet for delivering a beneficial agent to a mammal, comprising the steps of:

• forming a core compartment including a first end wall, an oppositely disposed second end wall, a sidewall between the first and second end walls, a diaphragm having a first side and a second side, a beneficial agent positioned on one of the first and second sides, and a push means positioned on the other one of first and second sides, the diaphragm constructed and arranged to be slideble within the core compartment;
• and
• surrounding the core compartment with a unitary shell.