Poly(ethylene glycol) derivatives with proximal reactive groups
AssigneeShearwater Corporation
InventorsJ. Milton Harris, Antoni Kozlowski
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Abstract
An activated, substantially water soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups. The free reactive groups are capable of reacting with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated poly(ethylene glycol) and the biologically active agent.
Claims21
An activated, water soluble polymer comprising a poly(ethylene glycol) polymer backbone having at least one terminus bonded to the structure
- wherein Y is a hydrolytically stable linkage, and X and X′, which may be the same or different, are reactive groups comprising a reactive moiety.
The polymer of claim l, wherein X and X′ are —W—Z and —W′—Z′, respectively, wherein Z and Z′ are said reactive moieties, and W and W′ are tethering groups.
Dependencies are inferred from the claim text.