Materials and methods for the analysis of substances passing through a membrane
OwnerEdward Allan Ross, Ian R. Tebbett +3inventors
InventorsEdward Allan Ross, Ian R. Tebbett, Charles J. Schmidt, Timothy Patrick Griffin, Margaret Wheland Couch
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Abstract
The subject invention pertains to the efficient and accurate detection and analysis of materials passing through a membrane. In a specific example the transport of materials through skin is analyzed. The subject method can allow accurate, precise, and specific real time measurements of compounds crossing a membrane. Accordingly, the subject method can save time in product development of pharmaceuticals, cosmetics, and protective clothing products, and can also reduce the need for animal and human testing.
Claims21
A method of studying a transport characteristic of a substance through a barrier, comprising the following steps:
- exposing a first side of a barrier to a substance;
- and
- measuring an amount of said substance exiting a second side of said barrier, wherein said barrier is positioned in a MIMS probe, wherein the step of exposing the first side of the barrier to the substance is accomplished by placing said substance in a sample chamber of the MIMS probe, and wherein said MIMS probe is positioned in a mass spectrometer such that the step of measuring the amount of said substance exiting the second side of said barrier is accomplished when said substance exiting the second side of said barrier is detected by the mass spectrometer.
A device for studying a transport characteristic of a substance through a barrier, comprising
- a means for exposing a first side of a barrier to a substance;
- and
- a means for measuring an amount of said substance exiting a second side of said barrier,
- wherein said barrier is positioned in a MIMS probe, wherein the means for exposing the first side of the barrier to the substance is adapted for placing said substance in a sample chamber of the MIMS probe, and wherein said MIMS probe is positioned in a mass spectrometer such that measuring the amount of said substance exiting the second side of said barrier is accomplished when said substance exiting the second side of said barrier is detected by the mass spectrometer.
Dependencies are inferred from the claim text.