Antimicrobial peptide compositions and method
AssigneePence, Inc.
InventorsLeslie H. Kondejewski, Robert S. Hodges, David S. Wishart, Robert E. W. Hancock, Ronald N. McElhaney, Elmar J. Prenner, Ruthven N. A. H. Lewis
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Abstract
The invention concerns antimicrobial cyclic peptides and peptide analogs having relatively low hemolytic activity. Peptides of the invention are effective in killing and/or inhibiting growth of a number of microorganisms, including gram-positive bacteria, gram-negative bacteria, fungi and mycoplasma. Also disclosed are methods for inhibiting or killing such microorganisms, and therapeutic preparations for such inhibiting or killing.
Claims11
A 14-mer cyclic peptide having an amino acid substitution in the amino acid sequence V1-K2-L3-K4-V5-Y6-P7-L8-K9-V10-K11-L12-Y13-P14 also identified by SEQ ID NO:
- 1, where Y represents D-tyrosine, numerals represent relative positions in said peptide, P14 is linked to V1, and said amino acid substitution is a D-amino acid in at least one of positions 1-5, 7-12 and 14, or an L-amino acid in position 6 or 13, and further characterized by a therapeutic index of greater than 1, wherein said therapeutic index value is determined as a ratio of the concentration of peptide required to produce hemolysis of human red blood cells divided by the concentration of peptide required to inhibit growth of a specified microorganism.
Dependencies are inferred from the claim text.