Methods of identifying inverse agonists of the serotonin 2A receptor
AssigneeAcadia Pharmacueticals Inc.
InventorsDavid Weiner, Mark R. Brann
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Abstract
The present invention relates to a method of identifying compounds which act as inverse agonists of the 5-HT2A receptor, the method comprising contacting a constitutively active 5-HT2A receptor with at least one test compound and determining any decrease in the level of basal activity of the receptor so as to identify a test compound which is an inverse agonist of the 5-HT2A receptor. Such inverse agonists may be used in the treatment of schizophrenia and related psychoses.
Claims11
A method of identifying a compound with antipsychotic activity, the method comprising:
- (a) contacting a 5-HT2A receptor having wild type constitutive activity with at least one test compound;
- and
- (b) determining any decrease in basal activity of the 5-HT2A receptor having wild type constitutive activity, wherein a decrease in basal activity of the 5-HT2A receptor identifies a compound with antipsychotic activity.
A method of identifying a compound with antipsychotic activity, the method comprising:
- (a) culturing cells which express a 5-HT2A receptor having wild type constitutive activity;
- (b) incubating the cells with at least one test compound;
- and
- (c) determining any decrease in basal activity of the 5-HT2A receptor having wild type constitutive activity, wherein a decrease in basal activity of the 5-HT2A receptor identifies a compound with antipsychotic activity.
A method of identifying a compound useful in treating the symptoms of disease or disorder associated with constitutive activity of the 5-HTA receptor, the method comprising:
- (a) contacting a 5-HT2A receptor having wild type constitutive activity with at least one test compound;
- and
- (b) determining any decrease in basal activity of the 5-HT2A receptor having wild type constitutive activity, wherein a decrease in basal activity of the 5-HT2A receptor identifies a compound useful in treating the symptoms of disease or disorder associated with constitutive activity of the 5-HTA receptor.
Dependencies are inferred from the claim text.