Graft polymerization of substrate surfaces
AssigneeSTS Biopolymers, Inc.
InventorsGuo-Bin Wang, Xianping Zhang
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Abstract
The invention includes a method of coating a substrate, comprising exposing a substrate to an initiator capable of initiating a graft polymerization reaction on the substrate, to generate reactive radical sites on the surface of the substrate; contacting the substrate with a composition comprising one or more monomers in a medium which has different hydrophilicity compared to the substrate, and grafting monomer molecules onto the substrate by forming covalent bonds between monomer molecules and the substrate at reactive radical sites on the substrate surface. With the invention, novel coated articles can be obtained which are particularly usefull as medical products such as catheters.
Claims39
A method of coating a substrate, comprising:
- exposing a substrate to an initiator in solution capable of initiating a graft polymerization reaction on the substrate, to generate reactive radical sites on the surface of the substrate;
- contacting the exposed substrate having reactive radical sites with a composition comprising one or more monomers in a medium which has reversed phase properties compared to the substrate, in terms of hydrophilicity and further comprising a solute in an amount sufficient to induce a salting-out effect;
- and
- graft polymerizing onto the substrate by forming covalent bonds between monomer molecules and the substrate at reactive radical sites on the substrate surface.
A method of coating a substrate, comprising:
- exposing a substrate to an initiator in solution capable of initiating a graft polymerization reaction on the substrate, to generate reactive radical sites on the surface of the substrate;
- contacting the substrate with a composition comprising one or more monomers in a medium which has reversed phase properties compared to the substrate, in terms of hydrophilicity and a concentration of a solute sufficient to induce a salting-out effect, while mixing the composition;
- graft polymerizing onto the substrate by forming covalent bonds between monomer molecules and the substrate at reactive radical sites on the substrate surface;
- and
- contacting the substrate with a cross-linking agent.
A method of coating a substrate, comprising:
- exposing a substrate to an initiator in solution capable of initiating a graft polymerization reaction on the substrate, to generate reactive radical sites on the surface of the substrate;
- contacting the substrate with a composition comprising one or more monomers in a medium and a concentration of a solute sufficient to induce a salting-out effect;
- and
- graft polymerizing onto the substrate at a pressure less than about 50 atmospheres by forming covalent bonds between monomer molecules and the substrate at reactive radical sites on the substrate surface.
Dependencies are inferred from the claim text.