Calcium phosphate microcarriers and microspheres
AssigneeCaP Biotechnology, Inc.
InventorsL. Brian Starling, James E. Stephan
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Abstract
The present invention provides calcium phosphate-based (CaP) microcarriers and their use, for example, in cell culturing systems, chromatography, and implantable biomedical materials.
Claims32
A biomedical implant comprising a hollow microbead of a calcium phosphate material, wherein the microbead has a density from about 25% to about 75% of the material's theoretical density.
A chromatographic column comprising an aggregate of hollow microbeads of a calcium phosphate material wherein the microbeads have a density from about 25% to about 75% of the material's theoretical density.
A microbead, wherein said microbead:
- is selected from the group consisting of hollow microbeads and solid microbeads;
- is selected from the group consisting of glass microbeads and polymer microbeads;
- and
- is formed with or coated with a particulate calcium phosphate.
A microbead, wherein said microbead is selected from the group consisting of hollow microbeads and solid microbeads, and wherein said microbead is a composite of (i) a calcium phosphate and (ii) a material selected from the group consisting of a ceramic material and a polymeric material.
An aggregate comprising microbeads having foamed structures of a material selected from the group consisting of ceramic, glass, and polymeric materials and composites thereof;
- wherein said foamed structures are selected from the group consisting of closed pores, open pores and combinations of closed and open pores;
- and wherein said aggregate is selected from the group consisting of a suspendable aggregate and a non-suspendable aggregate.
A biomedical implant, comprising an aggregate of hollow calcium phosphate (CaP) microbeads, wherein the microbeads have a density from about 1.0 grams/cc to about 2.0 grams/cc, wherein the microbeads are bonded by cementations agents.
A hollow calcium phosphate (CaP) microbead having a density from about 1.00 grams/cc to about 2.00 grams/cc and comprising a compound selected from the group consisting of a biological coating and a pharmaceutical agent.
Dependencies are inferred from the claim text.