Estrenes for inducting hypothalamic effects

A composition for nasal administration to the vomeronasal organ of a human, comprising one or more nasally pharmaceutically acceptable carriers and, per unit dose, an effective amount sufficient to stimulate the nervous system through interaction with the vomeronasal organ between about 100 picograms and about 1 microgram, of a compound of the formula:

• where:
• R1 is selected from the group consisting of one or two hydrogen atoms, one or two halogen atoms, methyl, and methylene;
• R2 is absent, or is selected from the group consisting of hydrogen and methyl;
• R3 is selected from the group consisting of oxo, hydroxy, lower alkoxy, lower acyloxy, benzoyl, cypionyl, glucuronide, or sulfonyl;
• R4 is selected from the group consisting of hydrogen, hydroxy, lower alkoxy, lower acyloxy, oxo, and halo;
• R5 is absent, or is selected from the group consisting of hydrogen, hydroxy, lower alkoxy, and lower acyloxy;
• R6 is hydrogen or halogen;
• and
• “a” represents optional unsaturation of the A ring of the compound;
• or
• “b”, “c”, “d”, “e”, “f”, “g”, “h”, “i”, and “j” are each optional double bonds.