Solution and method for treating autologous tissue for implant operation
AssigneeThe International Heart Institute of Montana Foundation
InventorsCarlos M. G. Duran, David T. Cheung, David C. Pang
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Abstract
An aqueous solution containing a water miscible organic solvent, polyethylene glycol and heparine, is used to modify the tissue reactivity of an autologous tissue freshly obtained from a host mammal and to render the tissue temporarily more rigid than in its native state, and better suited for shaping, molding, handling and cutting prior to implantation into the host patient. The implant is highly resistant or immune to thickening, contraction and reduced fibrin deposition after it is implanted and exposed to the bloodstream of the host.
Claims25
An aqueous composition adapted for treating autologous biological tissue for modifying its tissue reactivity and for rendering the tissue temporarily more rigid than in its natural state, the composition comprising:
- approximately 10 to 70% by volume of a water miscible non-toxic organic solvent selected from the group consisting of an alcohol having 1 to 3 carbons, acetone, acetonitrile and methyl ethyl ketone;
- approximately 2 to 30% by weight of polyethylene glycol having a molecular weight in the range of approximately 6,000 to 15,000 D;
- approximately 0.01 to 1.0% by weight of heparin, and
- the balance of the composition substantially consisting of water.
An aqueous liquid composition adapted for treating autologous biological tissue for modifying its tissue reactivity and for rendering the tissue temporarily more rigid than in its natural state, the composition comprising:
- approximately 15 to 60% by volume of ethyl alcohol;
- approximately 2 to 10% by weight of polyethylene glycol of a molecular weight of approximately 8,000 D;
- approximately 0.1 to 0.7% by weight of heparine, and
- the balance of the composition substantially consisting of water.
A method for modifying the tissue reactivity of an autologous tissue freshly obtained from a host mammal and for rendering the tissue temporarily more rigid than in its native state, the method comprising:
- exposing said autologous tissue to an aqueous composition, comprising:
- approximately 10 to 70% by volume of a water miscible non-toxic organic solvent selected from the group consisting of an alcohol having 1 to 3 carbons, acetone, acetonitrile and methyl ethyl ketone;
- approximately 2 to 30% by weight of polyethylene glycol having a molecular weight in the range of approximately 6,000 to 15,000 D;
- approximately 0.01 to 1.0% by weight of heparin, and
- the balance of the composition substantially consisting of water.
Dependencies are inferred from the claim text.