Cardiac pacing using adjustable atrio-ventricular delays
AssigneeCardiac Pacemakers, Inc.
InventorsJiang Ding, Yinghong Yu, Andrew P. Kramer, Julio Spinelli
Life of this patent
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Abstract
A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
Claims28
A method, comprising:
- selecting a cardiac reference event which repeats every cardiac cycle;
- selecting a cardiac variable event which changes as a function of a cardiac performance parameter, the cardiac performance parameter related to optimal atrio-ventricular delay;
- measuring an intrinsic time interval between the cardiac reference event and the cardiac variable event in an unpaced condition;
- ascertaining an optimal atrio-ventricular delay for optimizing the cardiac performance parameter;
- collecting intrinsic time intervals and optimal atrio-ventricular delays for a number of patients;
- producing a mathematical relationship for the intrinsic time intervals and the optimal atrio-ventricular delays.
A method, comprising:
- selecting a cardiac reference event which repeats every cardiac cycle;
- selecting a cardiac variable event which changes as a function of a cardiac performance parameter, the cardiac performance parameter related to optimal atrio-ventricular delay;
- measuring an intrinsic time interval between the cardiac reference event and the cardiac variable event in an unpaced condition;
- ascertaining an optimal atrio-ventricular delay for optimizing the cardiac performance parameter, including:
- applying a pacing signal with varying atrio-ventricular delays while monitoring the cardiac performance parameter;
- and
- determining an optimal atrio-ventricular delay for optimizing the cardiac performance parameter;
- collecting intrinsic time intervals and optimal atrio-ventricular delays for a number of patients;
- and
- producing a mathematical relationship for the intrinsic time intervals and the optimal atrio-ventricular delay pairs.
Dependencies are inferred from the claim text.